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IPA™ Integrated Patch Amplifier and Data Acquisition System

Sutter Instruments IPA™ Integrated Patch Amplifier

The IPA system combines state-of-the-art amplifier technology with a fully integrated internal D/A and A/D conversion and a high speed USB interface. Acquisition, data management, and streamlined analysis are performed using the bundled SutterPatch™ Data Acquisition and Analysis Software, built on the foundation of Igor Pro 7 (WaveMetrics, Inc.).
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IPA

Sutter Instruments IPA™ Integrated Patch Amplifier

Available spring 2016

Introducing the IPA™ Integrated Patch Amplifier, which enables efficient, low-noise whole cell recordings. The IPA system combines state-of-the-art amplifier technology with a fully integrated internal D/A and A/D conversion and a high speed USB interface. Acquisition, data management, and streamlined analysis are performed using the bundled SutterPatch™ Data Acquisition and Analysis Software, built on the foundation of Igor Pro 7 (WaveMetrics, Inc.).

External Inputs & Outputs

External signals, such as environmental parameters or stimulus information, can be recorded using 4 auxiliary analog input channels. The IPA system also supports control of peripheral hardware, such as wavelength or solution switchers, with 2 analog and 8 digital (TTL) output channels. With SutterPatch™ software, control of other Sutter Instrument devices requires no additional setup.

SutterPatch™ Software

The IPA system, in combination with SutterPatch software, has been engineered to automatically capture and store all amplifier settings, stimulus information and external experiment parameters and associate them in time with the raw data traces. This includes all amplifier and acquisition settings, as well as timing and progress of the experiment. Fully integrated computer control of the amplifier means that the acquisition software is aware of the internal state of the amplifier and digitizer at all times and can track any changes that may occur. This is independent of whether a change is triggered automatically or initiated by the user.


Tracking of Other External Data

In addition to status changes in connected hardware that are automatically tracked, the experimenter can manually trigger tags to document events like stimulus application in instruments not connected to the IPA system. Information about environmental parameters and a more detailed specification of sample properties, can be recorded and stored with the raw data. A total of over 500 metadata attributes are supported. Examples include: animal species, strain, and gender; date and time when a cell sample was prepared; the pH of the dissociation solution; pipette pull program; recording solutions; the operator name; pipette resistance; a large variety of automatically detected hardware properties; and detailed information about stimuli applied in the course of the experiment.

Data Visualization and Analysis

SutterPatch software has been designed to simplify the navigation and analysis of complex datasets. The scope window supports multiple view modes in both two-dimensional and an innovative three-dimensional display. The 3D view is particularly useful during assay development. Built on top of the latest version of the proven Igor Pro platform, the SutterPatch program combines native Igor Pro functionality with a wealth of features that are tailored to electrophysiology applications. Both the newcomer and experienced user of patch clamp programs will feel comfortable using SutterPatch software.

Both whole-cell voltage and current clamp experiments can easily be performed on the IPA system.
  • Typical applications
  • Tissue slice recordings
  • Cultured cell experiments
  • Cell line studies from adherent or dispersed cells
  • In-vivo patch clamp
  • Network studies
  • Optogenetics

Features

Fully integrated patch clamp amplifier and data acquisition system ensures quick and easy setup
Optimized for whole-cell patch clamp recordings in tissue slices, adherent or dissociated cells
Full computer control provides automated compensation of electrode and whole cell capacitance
Voltage and current clamp capability for complete characterization of cells' electrical activity
Bundled SutterPatch™ software excels in comprehensive data management, intuitive navigation and streamlined data analysis

Technical Specifications

  • Amplifier
  • 500 MΩ headstage feedback resistor provides a max. range of ±20 nA
  • Fast and slow capacitance compensation and whole-cell compensation
  • Fast compensation up to 25 pF; Slow compensation to 2.5 pF
  • Whole-cell compensation: Cm from 1-100 pF ; Rs from 1-100 MΩ
  • Automatic compensation routines
  • Series resistance prediction and correction (0-100 MΩ)
  • Four-pole Bessel low-pass filter (cutoff = 0.5 – 20 kHz)
  • Output gain : 1,2,5,10,20,50,100
  • Holding potential ±1000 mV
  • Current injection ±20 nA
  • Current clamp bridge compensation and capacitance neutralization
  • Slow holding potential tracking compensates for drift during current clamp recordings
  • Data Acquisition
  • Embedded data acquisition system eliminates the need for an external data acquisition board
  • Single high-speed USB connection controls data acquisition and amplifier
  • Up to 300 kHz aggregate sampling rate
  • Up to 6 input channels (1 - 50 kHz sampling rate per channel)
  • Holding potential command (1-10 kHz sampling rate per channel)
  • Auxiliary input / output for control of other instrumentation
  •     4 analog input channels (+/- 10V)
  •     2 analog output channels (+/- 10V)
  •     8 digital output channels (TTL)
  • Data acquisition can be initiated by an onboard microsecond clock or external (TTL) trigger
  • SutterPatch™ Software
  • Built on the foundation of Igor Pro 7 (WaveMetrics, Inc.)
  • Comprehensive data analysis routines and publication quality graphics
  • Routine editor provides complete experimental control
  • Associated metadata stores all relevant information regarding your experiment
  • Requires Windows 7 or later (Mac OS X support pending)