You are here:   Products
  |  Login

Categories

Minimize

All Products

Enquiry List

Minimize

Your Enquiry List is empty

Products

Minimize
iPRECIO logo
iPRECIO in hand
Close-up iPRECIO
blister-pack
Management System
Multi-pack
Detail

Primetech iPRECIO SMP-200 - Implantable Micro Infusion Pump

Implantable, Programmable Micro Infusion Pump for Small Animal Infusion
Code
iPRECIO SMP-200

Primetech iPRECIO SMP-200 - Implantable Micro Infusion Pump






The World's First Totally Implantable, Programmable Micro Infusion Pump for Small Animal Infusion

“This implantable infusion pump uses a patented, microprocessor controlled peristalsis mechanism for accurate controlled flow. It is the only implantable and programmable pump for small laboratory animals. iPRECIO® can infuse fluids continuously for as long as six months and it can be refilled via a percutaneously accessible port. ”

·         Accurate patented Rotary Finger Method

o   Every pump is factory tested and calibrated

Better than ±5% accuracy

o   0, 0.2, 0.5 and 1.0µl/hour to 30.0 µl/hour in 0.1µl/hour steps

294 discreet infusion flow-rates

o   Programmable infusions protocols (simple and complex)

·         Battery life of up to 6 months (continuous 1.0µl/hour)

·         Totally implanted in subcutaneous space

·         Refillable (reservoir) percutaneously via refill port with re-sealable septum

·         With iPRECIO® catheters, test your drug's effects nearly anywhere

·         Easy to use menu driven software for infusion protocol programming


Implantable


The pump can be completely implanted in small laboratory animals subcutaneously. Thus, the animal moves freely without any restrain (i.e. tethering) during drug infusion. Additionally, infection risk is reduced, and the animal is likely to be significantly less stressed than in a tethered infusion model.

Refillable


You can replenish any medical fluid in the pump via percutaneous access to the pump refill septum and reservoir after implantation of the pump. So, long-term drug infusion can continue until the installed battery life has run out. The reservoir is elastic and configured in such a geometry as to allow gentle palpation to confirm an approximate level of fluid in the reservoir.

Programmable

Infusion Mode

1. Instant Infusion :

Start infusion of the drug instantly by pre-programmed protocol following activation of the pump drive.

Instant Mode Setting Window :
Input the administration start date and time.

 

2. Post Recovery (Delayed) Infusion :

Start Infusion of the drug after reservoir contents are exchanged percutaneously following recovery period from implantation surgery by pre-programmed protocol. The pump infuse saline or buffer during the recovery period.



Post Recovery Mode Setting Window :

When using Post Recovery Mode, user will need to input both RCV Setup (start time, flow-rate, …) and administration protocol (start time, flow-rate, ….) . Total dead volume information will also need to be calculated by the iPRECIO® Management software.

Total dead volume consists of the fundamental dead volume of the iPRECIO® pump and the dead volume of the catheter. Catheter dead volume will include the total remaining length of iPRECIO® catheter and any additional attached catheters. User will need to input this accurately to obtain the accurate results.

 

Flow Rate Mode

1. Constant Flow Rate :

Configure one constant flow rate for infusion

Constant Flow Rate Mode Setting Window :
User inputs the duration of infusion.

*The software automatically shows the maximum duration based on the Dose/Flow Rate, Battery Life, Animal Body Weight.

 

2. Variable Flow Rate :

Configure up to 10 discrete infusion "steps" between 1μL/hr to 30μL/hr

Variable Flow Mode Setting Window :
User inputs the different flow steps.

This window is also used for Repeat Mode Setting.

(1) 3 groups shown.
(2) Set number of times to repeat each group.

 

Repeat Mode :

Repeat Mode allows the 10 flow steps to be used in a more sophisticated Infusion protocol where up to 2500* steps may be programmed. Therefore infusing protocols taking into account circadian rhythm, oral drug intake (3-4 times per day) or studies for dose response curves may be programmed.
* 10 steps x 250 times repeated (subject to battery life)

 

Combination of the Infusion Mode & Flow Rate Mode

User can select each combination between the infusion mode and flow rate mode.

  Infusion Mode Flow Rate Mode Description
1 Instant Infusion Constant Flow Rate The pump starts administration instantly at the pre-programmed start time & date and continues to infuse for the pre-programmed flow-rate and duration.
2 Instant Infusion Variable Flow Rate The pump starts administration instantly at the pre-programmed start time & date and continues to infuse at the various pre-programmed flow-rate steps and durations.
3 Post Recovery Infusion Constant Flow Rate The pump starts administration after the animals convalescence period following surgery.
During the convalescence/recovery period saline is infused at a programmable constant flow-rate. On completion of the recovery period, the pump operates as described in instant constant flow-rate.
4 Post Recovery Infusion Variable Flow Rate The pump starts administration after the animals convalescence period following surgery.
During the convalescence/recovery period saline is infused at a programmable constant flow-rate. On completion of the recovery period, the pump operates as described in instant variable flow-rate.

 

Management Software < 4 steps >

 

<Input General Information of the study>

Study Name, Number/ ID, Date, Animal Species, Strain, Age, Compound Name/ID, Concentration, Buffer Name, Administration Route, Number of Groups and Animals, etc.
 
<Animal Groups Settings>

# User inputs the concentration of solution and estimated maximum/minimum body weight expected of a subjected animal at the end of the study. Then the software automatically calculate the maximum/minimum dose which can be administered during the experiments.

# User selects either “Infusion Mode” or “Flow Rate Mode” and inputs the dose or flow rate of solution which will be administered.

** User can select the software types of “20 Groups x 20 Animals” or “50 Groups x 50 Animals”.
 
<Advanced Settings of the Infusion/Flow Rate Modes>

User program infusion protocol as infusion mode and flow rate mode for each animal/pump. Also user input Animal ID, Body Weight, Sex at this step.
 
<Download of the Protocol Settings to the each Pump>

Check the infusion protocol and schedule set for each animal/pump and download its protocol into the memory installed inside of the pump.

 

*Status Manager Window(Off-line monitoring)
You can confirm the administration schedule and the remaining volume of the pump reservoir, refill date, record the factual refill date, upload the log data of the pump.



Data Communication (IR)


IR communications are used for loading the infusion program and activating the pump. It is made directly without removal from the blister pack. Therefore sterility is maintained until the pump is taken to the sterile surgical suite for filling/activation and implantation.

Unique S/N ID with factory calibration data


Each pump's unique ID and calibration factor is read from each pump during the programming phase.

GLP Compliance



For GLP compliance, accuracy of flow infusion can be validated.
In addition, the iPRECIO can be user calibrated.

User log-in and password control options are available to the study director to restrict access to iPRECIO Management Software.

Long battery Life


The battery life is up to 6 months at a flow rate of 1.0μL/hr continuously.
You can confirm the estimated battery life on the PC Screen when you set the infusion protocol with the iPRECIO Management Software.

Flow Rate

Infusion Time

Total Volume

Time (h)

days (approx)

30.0μL/hr 196 hr 1 week 5.8 ml
19.0μL/hr 307 hr 1.8 weeks 5.8 ml
8.5μL/hr 669 hr 1 Month 5.6 ml
1.0μL/hr 4,328 hr 6 Months 4.3 ml

Precision



The technology driving the infusion is a patented "Rotary Finger" method. This method is a unique form of peristalsis.
The precise "micro-stick" pushes a rubber tube in the pump in a uniform and sequential manner.
The accuracy of iPRECIO is +/-5%.



Specifications

Micro Infusion Pump iPRECIO®

Infusion Method Rotary Finger Method (patented peristalsis) 
Reservoir
900μL Built-in Elastic Reservoir
(Medical Grade SIBS)
Tubing
Inner Tubing :
Outer Tubing :

 Medical Grade SEBS
Medical Grade SEBS
Activation Method   
Data Communication
 IR Communication
Range of Flow Rate  1.0μL/hr - 30.0μL/hr (Resolution : 0.1μL)
Accuracy < ± 5 % (under 0 – 80cm H2O pressure)
Battery Life   6 Months at 1.0μL/hr - 1 week at 30.0μL/hr
Size / Weight  38.7 (L) X 19.2 (W) X 9.7 (H) mm / 7.9g
Type of Usage  Disposable
Package  Sterilized blister package (5pcs/box)

If you would like to try iPRECIO pumps for yourself, you can purchase some pumps and we'll loan you a management system whilst you evaluate the system.