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Ugo Basile 38500 - P.A.M. Pressure Application Measurement

The P.A.M. (Pressure Application Measurement) device is a novel tool for measuring mechanical pain threshold.
Code
38500

Ugo Basile 38500 - P.A.M. Pressure Application Measurement

The P.A.M. (Pressure Application Measurement) device is a novel tool for measuring mechanical pain threshold. It was specifically designed and validated for Arthritis research and is therefore especially suited to assess joint hypersensitivity in rodents knees or ankles.

The PAM device can also be used to measure mechanical sensitivity in mice and rats paw, by using a specific Paw Pressure Transducer (optional).

The PAM device t applies a quantifiable force for direct stimulation of the joint and for automatic readout of the response.

The operator simply wears a special force sensor on his or her thumb and the peak amplifier measures the force which elicits the animal response (normally, limb withdrawal).

Each PAM device comes standard with two force sensors, which have been specially designed to apply force to rat and mouse joints.

The device includes as standard both a control unit with internal memory and the NEW DCA software for signal monitoring, data transfer and analysis. Once saved, data can be browsed on the control unit and/or trasferred to a PC in proprietary, Excel (.xls) or text (.txt) format, to be managed by most statistical analysis packages available on the market.

Features & Benefits

FEATURE
 BENEFIT
 The force is applied directly to the joint  Direct measurent of evoked pain
 Specifically designed for arthritis research  The applicators are shaped for rodents knee and ankle
 Paw pressure transducer is an optional  PAM can also be used as a hand-held Randall-Selitto device

Specifications

  • Resolution: 0.1g
  • Maximum applicable Force: 1500g
  • Weight 1.4Kg
  • Shipping Weight 2.7Kg
  • Packing 46x38x27cm

Application

Arthritis is associated with chronic, debilitating pain in the joints. Current metrics of arthritic pain in animal models are indirect, by scoring the level of motor activity or the animal weight distribution (Barton et al. 2007); while correlating well with the level of joint pain, their metric is a composite picture of complex pain responses, and provides little direct information about local stimulation and locally-evoked responses.

The quantification of localized joint hypersensitivity is not common in animal experiments; in this sense the PAM device represents a step forward toward multifactorial measurement of pain-related behavior in animal research; the PAM is the first instrument designed specifically to apply force to the joint and automatically detect the animal response.

Components & Accessories

38500 PAM, standard package, including the following components:

38500-001 Electronic Unit

38500-002 Large Joint Transducer

38500-003 Small Joint Transducer

38500-011 DCA Software (on USB Key)

38500-302 Instruction Manual (on USB Key)

38500-303 Pedal Switch

All components lodged in a dedicated plastic case

Options

38500-006 Paw Transducer

38550 PAM, high-pressure model for large animals

Bibliography

Method Paper

Acknowledgements:

The PAM device was invented and validated in the University of Edinburgh by the team of Prof. Daniel McQueen, Susan Bond and colleagues and Dr. Harry Brash, who built the first prototypes.