Automated Blood Sampler

New Automated Blood Sampler

User defined sampling schedule
Uses one fluid channel for sampling and infusion
Integrated fraction collector
In-line sensors continually monitor dilution
Auto-retry and operator alert functions

This new system automates the collection of blood samples from a range of species.  By eliminating the need for labour-intensive manual withdrawals, the samplers can streamline pharmacokinetic studies.  Exogenous or endogenous compound levels that could be effected by the stress of handling can be measured more accurately since the subjects is not even aware that a sample is being drawn.

The sampler is compact (only 6 inches high) and can be set up above your existing cages.  Each sampler employs four precision peristaltic pumps to withdraw blood from a freely-moving subject,  it then stores the samples in an integrated refrigerated fraction collector, and replaces the withdrawn volumes with IV fluid.  This all takes place using a single fluid channel which leaves you free to use an additional channel (when using a dual channel swivel) for drug infusion, blood pressure monitoring or other applications.

You can control and monitor sampling schedules, volumes and withdrawal rates for up to 12 samplers from a single PC or Laptop using the standard serial port connection.  The controlling PC can be located well away from the samplers, permitting remote control and further reducing exposure and stress to the subjects.

An automatic calibration routine gives you the flexibility to choose catheters and tubing sets that work best for you.  The sterile silicone tubing sets contain no valves, simplifying clean-up and replacement operations.

Each sampler includes a fifth pump for IV drug administration using a second fluid channel.  The system monitors proper movement of blood and IV fluid via two strategically located sensors, alerting the monitor to problems such as an occluded catheter and providing verification of successful operation in a log file generated after each sampling session.

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Five approaches to avoid sample loss due to clotting

A
Push-Before-Pull sampling technique infuses a pulse of IV fluid before drawing the sample.
B
The system can be set to infuse IV fluids through the catheter before, between and after scheduled samples at low KVO (Keep Vein Open) rate.
C
Optional CBAS (TM) Heparin-coated catheters have been shown to remain patent more than twice as long as uncoated catheters.
D
Lightly heparinized IV fluid recommended
E
If one of two upstream sensors detects a failed sample, the software will initiate an automatic retry routine and alert the operator.

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Specifications

Sample vials
Standard 1.5ml centrifuge tubes
Fraction collector type
10 well rotary (more than 10 samples possible once initial samples are removed)
Sample storage temperature
8 deg C
Maximum number of sampling events 
15 programmed, plus more on demand
Maximum duration of sampling session
Unlimited
Auto-retry routine
Skips to next sample if 2 attempts fail to pull in blood
KVO feature for catheter patency
5ul per pulse; integrated ul/hr adjustable
Time to take one sample
Varies based on parameter settings (typically 3-5 min)
Minimum collected sample volume
Approx. 25ul
Dilution of sample
None, if trim volumes are correctly set
Volume of blood withdrawn per sample
Sample volume plus typically 40-80ul (volume replaced by IV fluid)
Tee blood sensors
Electrical impedance technology
PC requirements
PC or Laptop with free serial (RS232) port, Windows 95/98, ME, 2000 or NT, 128MB RAM
Maximum number of samples per PC
12
Sampler communications method
RS485 using RS-232 serial port converter;4000 ft transmission capability
Sampler communications and sampler-sampler cable
6ft standard cable; other lengths can be supplied on request
Power supply
Desktop 12VDC @ 3A min; 100-240VAC input, 47-63Hz
Sampler power consumption
 Less than 40W per unit, excluding computer; UPS recommended
Sampler weight
7lbs (3kg)
Sampler dimensions
9.5"W x 10"D x 6.5"H (24 x 25 x 17cm)

For ordering information, or to find out more, please contact us or click on the button below and fill-in our enquiry form.

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Site by Rob Jones.
Copyright © 1999 Linton Instrumentation  . All rights reserved.
Revised: June 03, 2004 .